Details: | |
Tested Applications | WB, ELISA |
Target Information | A is a 35 kDa subunit of Shiga Toxin |
Product Format | Affinity Purified |
Alternate Names | SLT-2 A subunit, SLT-2a, SLT-IIa, Verocytotoxin 2 subunit A, Verotoxin 2 subunit A, rRNA N-glycosidase 2, stxA2, stx2A |
Clone | 1C6A6G9 |
Host | Mouse |
Isotype | IgG1 |
Immunogen | Peptide |
Epitope | a.a. 198 - 212 |
Relevance | The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits. After endocytosis, the A subnit is cleaved by furin in two fragments, A1 and A2: A1 is the catalytically active fragment, and A2 is essential for holotoxin assembly with the B subunits. |
Specificity | stxA2 |
Reported Reactivity | Unknown |
Reported Applications | Unknown |
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