产品名称：NeoClone/Sir1 Monoclonal Antibody/W0037

产品编号：W0037

市场价：¥5500.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>内参抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$275.00

品牌： NeoClone

公司：Neoclone

公司分类：

商品介绍

Details:
Tested Applications	ELISA, Western Blot
Target Information	Sir1 is a 76.9kDa, S. cerevisiaetranscription repressor, member of the Sir(Silent Information Regulator) family
Product Format	Affinity Purified
Alternate Names	Heterochromatin protein SIR1, Silent information regulator 1
Clone	1C12B12
Host	Mouse
Isotype	IgG1
Immunogen	Recombinant Protein
Epitope	Unknown
Relevance	Involved in the establishment, but not the maintenance, of heterochromatic silencing at the cryptic mating-type loci HMR and HML. Is recruited by interacting with the ORC1 subunit of the origin recognition complex (ORC), which binds to HML-I or HMR-E silencers, DNA elements that direct the formation of silent chromatin at the mating-type loci. Establishes transcriptional silencing by recruiting the three other SIR proteins, SIR2, SIR3, and SIR4, that function directly in silenced chromatin and establish repression. Also found in centromeric chromatin. Binds to and helps retain CAC1, a subunit of chromatin assembly factor I (CAF-I) at centromeric loci independent on the other SIR proteins.
Specificity	Yeast (Saccharomyces cerevisiae)
Reported Reactivity	Unknown
Reported Applications	Unknown

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